Exposure in utero to non-steroidal estrogens (diethylstilbestrol [DES]) also has been identified as a risk factor for:

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Multiple Choice

Exposure in utero to non-steroidal estrogens (diethylstilbestrol [DES]) also has been identified as a risk factor for:

Explanation:
Exposure to DES during fetal development acts like estrogen in the developing reproductive tract, causing vaginal adenosis and other Müllerian anomalies. This abnormal tissue environment can, in adolescence or young adulthood, give rise to malignant transformation, most characteristically a clear cell adenocarcinoma of the vagina. Therefore, the strongest and most specific cancer risk linked to in utero DES exposure is vaginal cancer. The other cancers listed do not show as clear or as strong an association with DES exposure as vaginal cancer.

Exposure to DES during fetal development acts like estrogen in the developing reproductive tract, causing vaginal adenosis and other Müllerian anomalies. This abnormal tissue environment can, in adolescence or young adulthood, give rise to malignant transformation, most characteristically a clear cell adenocarcinoma of the vagina. Therefore, the strongest and most specific cancer risk linked to in utero DES exposure is vaginal cancer. The other cancers listed do not show as clear or as strong an association with DES exposure as vaginal cancer.

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